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What is a 4th generation Oral Contraceptive?

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Drospirenone is what is known as a 4th generation progestin, which is an essential component in the newer and most popular oral contraceptives Yaz and Yasmin. Oral contraceptives that contain 4th generation progestins are accordingly referred to as 4th generation as well. That sounds simple enough, but the question is why the distinction?

First of all, progestins are synthetic (man-made) forms of progesterone, the presence of which inhibits ovulation among other physiological effects, which makes it the active ingredient for contraception. Naturally occurring progesterone is poorly absorbed by the body and rapidly degrades. Progestins, on the other hand, are more stable. The first generation of progestins was developed in 1951 and was first approved for use in the US as an oral contraceptive in 1960. These were estranes (steroids) derived from testosterone.

As the science improved, so did progestins. The aim for use in oral contraception is for high progestational selectivity and low androgenic effects. By the 4th generation, progestins not only prevented ovulation, but actually improved skin health and regulated menstrual cycles. As a result of these improvements, oral contraceptives using 4th generation progestins such as drospirenone seemed to be a godsend to all women of childbearing age.

However, with the good came the bad. Some time after Yasmin (2001) and Yaz (2006) were introduced into the market, concerns started to crop up regarding the apparent link between some cases of abnormal rates of blood clotting and drospirenone. Although the number of cases was relatively small, it still prompted the Food and Drug Administration to conduct studies regarding the high risk of blood clotting being attributed to drospirenone. The results of these studies were not conclusive but indicative of a serious problem with the products containing drospirenone.

Today, despite the big numbers being used in personal injury lawsuit against Bayer for using drospirenone in their products, 4th generation oral contraceptives are still widely prescribed and used. And because Bayer refuses to acknowledge that the company knew or should have known about the risks associated with using drospirenone and withheld the information from the public, or to confirm that the health risks are present, anyone who is adversely affected by using Yaz and Yasmin may still be able to sue for compensation.


Vimax Detox – Your Answer to a Sexy Physique and Healthy Colon

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Going on a diet and exercising to lose weight has been an obsession to many figure-conscious individuals, especially women, the world over. Probably the wait for a product that will really shed off those excess body fats is finally over with the Vimax Detox, now an enormously popular product.

Vimax Detox, a fat burner, is found to be an extremely powerful and effective colon cleanser. It has been clinically proven that this product is able to wash out every bit of junk in the body, increasing metabolism at the same time without any harm to the immune system and without requiring any significant change in diet and lifestyle. Nicole Kidman, Kylie Minogue and Janet Jackson are just a few of the very famous celebrities known to be using this diet cleanser.

The product is proven to: reduce weight 4 times more effective than diet and exercise; increase energy; be rich in antioxidants; and, promote digestive and cardiovascular health. Its ingredients include:

  • Psyllium Husk – this dietary fiber source boosts sluggish colon; it also an effective relief against diarrhea, irritable bowel syndrome and diverticular diseases.
  • Senna Leaf – a great remedy against constipation and an efficient appetite suppressant; this natural ingredient contains anthraquinone glycosides, which transports food before the body absorbs it.
  • Rhubarb Root – nature’s cure to constipation and diarrhea: this ingredient has been used for many centuries to remedy digestive problems.Apple Fiber – a great relief against hemorrhoids, colitis and other constipation-related symptoms; it is also an effective protection against high cholesterol and heart disease.
  • Ginger Root – a powerful antioxidant and is known to lower blood pressure and alleviate digestive problems.

Vimax Detox simply separates the “im” from “possible,” when it comes to losing weight. By flushing out toxins and intestinal parasites that build in the colon, you don’t only experience constipation relief; you will also feel your weight going down and your body slimming.